Cecilia Q. Xi;Yelena Nabutovsky;Jong Gill;Stuart Rosenberg;Brian J. Wenzel;William Hsu
发明人:
Stuart Rosenberg,Cecilia Q. Xi,Yelena Nabutovsky,Brian J. Wenzel,Jong Gill,William Hsu
申请号：
US13035793
公开号：
US08380303B2
申请日:
2011.02.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.
