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Formulations for parenteral administration of amino-substituted (E)-2, 6-dialkoxystyryl 4-substituted benzylsulfones
专利权人:
Manoj Maniar
发明人:
Stanley C. Bell,Manoj Maniar
申请号:
US12523305
公开号:
US08476320B2
申请日:
2008.01.16
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Formulations are provided for parenteral administration of (amino substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones and the sodium and potassium salts thereof for the prevention and/or treatment of conditions mediated by abnormal cell proliferation.Composition for parenteral administration are provided which comprise an effective amount of a compound of formula Ior a compound of formula IIaand at least about 50% by weight of at least one water soluble polymer selected from the group consisting essentially of polyethylene glycol (PEG), poly-oxyethylene, poly-oxyethylene-poly-oxypropylene copolymers, polyglycerol, polyvinylalcohol, polyvinylpyrrolidone (PVP), polyvinylpyridine N-oxide, copolymer of vinylpyridine N-oxide and vinylpyridine.
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