Heterocyclic compounds as inhibitors of bace 1 or 2； Pharmaceutical composition that comprises； Pharmaceutical Combination； and its use for the Treatment or prevention of Alzheimer's disease and mild cognitive impairment, insulin resistance, Type 2 diabetes, among others.
SANGAMESH BADIGER,MURALI CHEBROLU,KONSTANZE HURTH,SEBASTIEN JACQUIER,RAINER MARTIN LUEOEND,RAINER MACHAUER,HEINRICH RUEEGER,MARINA TINTELNOT-BLOMLEY,SIEM JACOB VEENSTRA,MARKUS VOEGTLE
申请号：
CL2013001964
公开号：
CL2013001964A1
申请日:
2013.07.03
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.<；p>；La invenció；n se refiere a compuestos heterocí；clicos derivados de [4, 5 o 6(3,6-dihidro-2H-(1,4)-oxazin-3-il)-(piridin)-2 o 3-il]-amida, inhibidores de beta-secretasa (BACE-1)； a composiciones farmacé；uticas de los mismos； y a su uso en el tratamiento o prevenció；n de la enfermedad de Alzheimer o un deterioro cognitivo leve.<；/p>；
