(In formula, as for R methyl, it is cyano or karubamoiru)So it contains the salt or those solvent dishes dressed with sauce which on chemical compound and the medicine manufacture which are shown is allowed, as the active ingredient the improvement medicine of the remedy medicine or ataxia or equilibrium obstacle of the spinal cord cerebellum denaturation symptom (spinocerebellar ataxia, atrophy and degeneration) or the polyphyletic atrophy symptom.(式中、Rはメチル、シアノまたはカルバモイルである)で示される化合物、その製薬上許容される塩、またはその溶媒和物を有効成分として含有する、脊髄小脳変性症(spinocerebellar ataxia, atrophy, degeneration)もしくは多系統萎縮症の治療剤または運動失調もしくは平衡障害の改善剤。