PRODUCTION AND THERAPEUTIC USES OF TH1-LIKE REGULATORY T CELLS

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专利权人:

发明人:

Dale Umetsu,Rosemarie Dekruyff,Omid Akbari,Philippe Stock

申请号：

US14869771

公开号：

US20160136204A1

申请日:

2015.09.29

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A unique CD4+CD25+ regulatory T cell population develops from naive CD4+CD25− T cells during a TH1 polarized immune response (called TH1-TR cells). These TH1-TR cells can be generated by contacting naïve T cells with mature CD8α+ dendritic cells (DCs) that have been exposed to a TH1 polarizing adjuvant and, in some cases, an antigen of interest. The TH1-TR are identified by their expression of the cytokines IL-10 and IFN-γ, the transcriptional regulators T-bet and FoxP3, and the cell surface molecules CD4, CD25, CD69, CD44 and ICOS.

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中国工程科技知识中心

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