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APPLICATION OF HSP90 INHIBITORS FOR THERAPEUTIC TREATMENT
专利权人:
НОВАРТИС АГ (CH)
发明人:
ГАРСИЯ-ЭЧЕВЕРРИЯ Карлос (CH),ЙЕНСЕН Микаэль Ругорд (CH),КВАДТ Корнелия (CH)
申请号:
RU2011126254/15
公开号:
RU2011126254A
申请日:
2009.11.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The use of an Hsp90 inhibitor for the manufacture of pharmaceutical compositions for use in the treatment of cancer of the bladder, colon and colon, rectum, liver, lung, chest, vagina, ovaries, pancreas, kidney, stomach, digestive tract, prostate, head and neck , skin, abdominal cavity, thyroid gland, bones, brain, central nervous system, endocrine system, thyroid gland, adrenal glands and / or blood, and / or myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multifocal oh Castleman's disease and / or psoriaza.2. The use according to claim 1, wherein the Hsp90 inhibitor is a compound of formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4 ) (C-C) alkoxy group, (5) thiol, (6) (C-C) alkylthiol, (7) substituted or unsubstituted (C-C) alkyl, (8) amino group or substituted amino group, (9) substituted or unsubstituted aryl, (10) substituted or unsubstituted heteroaryl and (11) substituted or unsubstituted heterocyclyl; R is selected from the group consisting of: (1) hydrogen, (2) substituted or unsubstituted (C-C) alkyl, (3) substituted or unsubstituted (C-C) alkenyl, (4) substituted or unsubstituted (C-C) alkynyl, (5) substituted or unsubstituted (C-C) cycloalkyl, (6) substituted or unsubstituted (C-C) cycloalkenyl, (7) substituted or unsubstituted aryl, (8) substituted or unsubstituted heteroaryl, and (9) substituted or unsubstituted heterocyclyl; R is selected from the group consisting of: (1) substituted or unsubstituted (C-C) cycloalkyl , (2) substituted or unsubstituted (C-C) cycloalkenyl, (3) substituted or unsubstituted aryl, (4) substituted or unsubstituted1. Применение ингибитора Hsp90 для изготовления фармацевтических композиций для применения при лечении рака мочевого пузыря, толстой и ободочной кишки, прямой кишки, печени, легких, груди, вагины, яичников, поджелудочной железы, почки, желудка, п
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