This invention disclosure provides culture surface compositions and methods that control the NPCs and NSCs, and/or MSCs to either largely maintain their phenotypes, or differentiate on these culture surfaces in guided lineage. The culture surface composition can be constructed to contain either OH functional groups, or —NH2 groups to control the adherence, migration, proliferation and differentiation of MSCs, providing a methods to direct NSCs lineage specification in neural tissue engineering for a wide variety of neurological diseases.
