An electrode patch and physiological signal device are disclosed. The physiological signal device includes an electrode patch and a physiological signal unit. The physiological signal unit has a conductive pad, and the electrode patch includes a flexible sheet having a first surface and a second surface opposite from each other, a conductive pad is disposed on the first surface, a conductive gel covers a portion of the conductive pad and a conductive area is exposed the conductive gel penetrates through the flexible sheet and is exposed on the second surface the second surface of the electrode patch contacts with the physiological signal unit, and the conductive gel is electrically connected to the conductive pad. The physiological signal unit is electrically connected to a charging device via the conductive area of the electrode patch. Thereby, the physiological signal unit can be placed on the charging device directly for charging.