The Board of Trustees of the Leland Stanford Junior University
发明人:
WEISSMAN, Irving L.,CZECHOWICZ, Agnieszka,BHATTACHARYA, Deepta,KRAFT, Daniel
申请号：
ES07871350
公开号：
ES2642205T3
申请日:
2007.11.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
