Freimoser-Grundschober Anne,Klein Christian,Moessner Ekkehard,Nicolini Valeria G.,Hofer Thomas U,Ast Oliver,Bruenker Peter,Herter Sylvia,Hosse Ralf,Umana Pablo
申请号：
NZ71074212
公开号：
NZ710742A
申请日:
2012.02.07
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is an immunoconjugate comprising a mutant IL-2 polypeptide and an antigen binding moiety, wherein the mutant IL-2 polypeptide is a human IL-2 molecule (SEQ ID NO:1) comprising the amino acid substitutions F42A, Y45A and L72G； and wherein the antigen binding moiety is an IgG1 subclass immunoglobulin molecule specific for FAP, comprising the heavy and light chains of the sequences as defined in the specification.
