The invention relates to a Pharmaceutical composition of a puff of a spray or inhaler for use in the treatment of sinusitis or/and COPD, by administration by inhalation to a human subject comprising at least one topical corticoid, a sugar alcohol, and an antiseptic wherein said topical corticoid is present in an amount between 10 and 1000 μg, the sugar alcohol being present in a percentage between 0.1 and 20, and the antiseptic present in a percentage between 0.001 and 5. This composition can be administered by nasal spray or dry powder inhaler and is used for treating the upper and lower respiratory tract, in particular sinusitis with or without polyps, as well as COPD or other respiratory deceases as mucoviscidosis.
