A prosthetic device (1, 100, 200, 300), adapted to be implanted in the human body and adapted to prevent and/or treat an infection that can arise and/or that has arisen in a bone or articulation site, wherein the prosthetic device comprises a prosthetic body (2, 102, 202, 302) provided with at least one surface for coupling, during use, with the bone or articulation site and with at least one cavity (4, 104, 204, 304) placed along the coupling surface, wherein the at least one cavity is adapted to comprise, contain or house at least one pharmaceutical or medical substance (4').
