Plants having one or more enhanced yield-related traits and a method for making the same are provided. It relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, a method for enhancing one or more yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a POI (Protein Of Interest) polypeptide is provided. Plants having modulated expression of a nucleic acid encoding a POI polypeptide are also provided, which plants have one or more enhanced yield-related traits compared with control plants. Hitherto unknown POI-encoding nucleic acids and constructs comprising the same useful in performing the method are also provided.