MÉTODO PARA TRATAR O MEJORAR TRASTORNOS METABÓLICOS MEDIANTE EL USO DE AGONISTAS DEL RECEPTOR Glp-1 CONJUGADOS CON ANTAGONISTAS DEL RECEPTOR DEL PÉPTIDO INHIBIDOR GÁSTRICO (GIPR)
HERBERICH, Bradley J.,YIE, Junming,NETIROJJANAKUL, Chawita,STANISLAUS, Shanaka,CHENG, Yuan,XU, Jing,FALSEY, James R.,HOLDER, Jerry Ryan,LU, Shu-Chen,WU, Bin,MIRANDA, Leslie P.,SHAM, Kelvin,VEN
申请号：
CR20190380
公开号：
CR20190380A
申请日:
2018.01.16
申请国别(地区):
CR
年份:
2019
代理人:
摘要：
Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
