LEV DAVIDOVICH RASNETSOV,IAKOV YUDELEVICH SHVARTSMAN,OLGA NIKOLAEVNA SUVORONA
申请号：
MX2013008867
公开号：
MX2013008867A
申请日:
2012.02.06
申请国别(地区):
MX
年份:
2014
代理人:
摘要：
The invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene С60 of general formula C60(H)3{NH(CH2)nCOO H}3â‹ xH2O, where С60 - fullerene, n = 5, 6, 7, Ñ = 8 - 10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N-fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60 °С until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumour and anti-psoriatic activity, comprising, as active substance, an effective quantity of hydrated N-fullerene amino acids.La invención se refiere a la industria farmacéutica y a la medicina, específicamente a nuevos derivados de aminoácidos de fulereno C60 hidratados de fórmula general C60(H)3{NH(CH2)nCOOH}3 xH2O, en donde C60 es fulereno, n = 5, 6, 7, x = 8 - 10, y también a un método para producir dichos derivados, y a la producción de composiciones farmacéuticas con base en los mismos. Los aminoácidos de fulereno hidratados se forman en la interacción de fulereno con un exceso molar de 15 veces de sales de potasio anhidro de aminoácidos en un medio de disolvente aromático orgánico con una adición lenta a la suspensión resultante de un catalizador de transferencia de fase y con mezclado y calentamiento a una temperatura no s
