ВЕНАНЦИ Франко (IT),КОНЧЕТТИ Антонио (IT),САББЬЕТИ Мария Джованна (IT),АГАС Димитриос (IT),ГАБАЙ Владимир (US),ШИФРИН Виктор (US),ШЕРМАН Майкл (US),ШНАЙДЕР Александр (US)
申请号：
RU2016128557
公开号：
RU2016128557A
申请日:
2014.12.29
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cytokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 compositions are useful for prophylaxis and treatment of inflammatory diseases and related methods. In certain embodiments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syndrome, type 2 diabetes, fat liver, inflammatory bowel disease, chronic pancreatitis, asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), osteoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative diseases (ALS, Parkinson, Alzheimers, Huntington disease), depression, schizophrenia, gout, asbestosis and silicosis.
