PROBLEM TO BE SOLVED: To provide an agent effective for various refractory skin diseases, specifically atopic dermatitis skin.SOLUTION: An external use composition for skin includes: a tarajo holly leaf extract and a Japanese knotweed leaf extract a brown algae extract and an egg shell membrane derived peptide (ESM-P) having a molecular mass of 3 kDa or higher. Preferably, the composition is used to treat a disease or condition of skin relating to a filaggrin metabolism anomaly, and has an effect of eliminating itches and pains based on inhibition of histamine release and cyclooxygenase (COX)-2 activity, an effect of regulating excessive immune response based on inhibition of cytokine generation, and an effect of normalizing epidermis formation based on acceleration of filaggrin synthesis.COPYRIGHT: (C)2012,JPO&INPIT【課題】種々の難治性皮膚疾患、特にアトピー性皮膚炎に有効な剤の提供。【解決手段】タラヨウ葉抽出物及びイタドリ葉抽出物、褐藻類抽出物、並びに分子量3kDa以上の卵殻膜由来ペプチド(ESM-P)を含有する皮膚外用用組成物。好ましくは、フィラグリン代謝異常に関連した皮膚の疾患又は状態を処置する組成物で、ヒスタミン遊離抑制、シクロオキシゲナーゼ(COX)-2活性阻害に基づく痒みや痛みの抑制作用、サイトカイン産生抑制による免疫の過剰反応の調節作用、及びフィラグリンの合成促進に基づく皮膚表皮形成の正常化作用を有する。【選択図】なし
