As for this invention, formula I:[In formula: R1 and formula I, formula Ia, R4, R5, formula Ib, R3, R3a, W, D, R2a, R2b and R2c are defined] chemical compound, and those all stereoisomers, solvation chemical compound, offer the professional drag and the salt which is allowed medicine at the time of this inventing. Furthermore, this invention includes the chemical compound at least by one expression I, offers the medicine constituent which at least as needed includes one another remedy medicine. Lastly, this invention offers the manner which it remedies the MCRH 1 adjustment disease or fault, for example obesity and diabetes, the u, the insecure symptom or the patient of the intestinal tract inflammation, in regard to remedy by prescribing the chemical compound of formula I of the effective tonnage.本発明は、式I:[式中:R1,式I、式Ia、R4、R5、式Ib、R3、R3a、W、D、R2a、R2bおよびR2cは本発明において定義される]の化合物、およびそれらの全ての立体異性体、溶媒和化合物、プロドラッグおよび医薬的に許容される塩を提供する。さらに、本発明は少なくとも一つの式Iによる化合物を含み、少なくとも一つの別の治療剤を適宜含む医薬組成物を提供する。最後に、本発明は、MCRH-1調節疾患または障害、例えば肥満、糖尿病、うつ、不安症または腸管炎症の患者を、治療上有効量の式Iの化合物を投与することにより治療する方法を提供する。
