Shunji Tomatsu,Adriana Montano,Tatsuo Nishioka,Jeffrey H. Grubb,William S. Sly,Monica A. Gutierrez
申请号：
US12714534
公开号：
US08226940B2
申请日:
2010.02.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient.
