COMPOSITIONS ET METHODES POUR L'UTILISATION THERAPEUTIQUE D'UNE SEQUENCE ASSOCIEE AU GENE ATONAL DANS LE TRAITEMENT DE LA SURDITE, DE L'OSTEOARTHRITE ET D'UNE PROLIFERATION CELLULAIRE ANORMALE
Compositions and methods are disclosed for the therapeutic use of an<；i>；atonal<；/i>；-associated nucleic acid or amino acid sequence. Also, an animalheterozygous for an <；i>；atonal<；/i>；-associated gene inactivation is alsodisclosed having at least one <；i>；atonal<；/i>；-associated nucleic acid sequencereplaced by insertion of a heterologous nucleic acid sequence used to detectexpression driven by an <；i>；atonal<；/i>；-associated promoter sequence, whereinthe inactivation of the <；i>；atonal<；/i>；-associated nucleic acid sequenceprevents expression of the <；i>；atonal<；/i>；-associated nucleic acid.
