FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new piperazine amide derivatives of formula wherein X represents N or CH； Y represents N or CH； R1 represents lower alkyl, phenyl, phenyl-lower alkyl wherein phenyl can be optionally substituted by 1-2 substitutes independently specified in a group consisting of halogen, lower alkyl； R2 represents lower alkyl, phenyl, naphthyl or heteroaryl specified in dimethylisoxazolyl, quinolinyl, thiophenyl or pyridinyl wherein phenyl or heteroaryl are optionally substituted by 1 substitute optionally specified in a group consisting of halogen, lower alkoxy group, fluor-lower alkyl, lower alkoxy-carbonyl and phenyl； R3 represents phenyl, pyridinyl or pyrazinyl wherein phenyl, pyridinyl or pyrazinyl are substituted by 1-2 substituted optionally specified in a group consisting of halogen, lower alkyl and fluor-lower alkyl； R4, R5, R6, R7, R8, R9, R10 and R11 independently represent hydrogen, as well as to their physiologically acceptable salts. These compounds are bound with LXR alpha and LXR beta, and are applicable as therapeutic agents for treatment and/or prevention of high lipid levels, high cholesterol levels, low HDL cholesterol, high LDL cholesterol, atherosclerotic diseases, diabetes, non insulin dependent diabetes mellitus, metabolic syndrome, dislipidemia, sepsis, inflammatory diseases, infectious diseases, skin diseases, colitis, pancreatitis, cholestasis, liver fibrosis, psoriasis, Alzheimer's disease, etc.EFFECT: preparing new piperazine amide derivatives.15 cl, 88 exИзобретение относится к новым пиперазинамидным производным формулы (I), где Х представляет собой N или СН； Y представляет собой N или СН； R1 представляет собой низший алкил, фенил, фенил-низший алкил, где фенил необязательно может быть замещен 1-2 заместителями, независимо выбранными из группы, состоящей из галогена, низшего алкила； R2 представляет собой низший алкил, фенил, нафтил или гетероарил, выбранный из диметилизоксазолила, хинолини
