benzothiazine derivatives, preparation thereof and application thereof as drugs

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专利权人:

PIERRE FABRE MEDICAMENT

发明人:

DIDIER JUNQUERO,MARIE LAMOTHE,MICHEL PEREZ,YVES RIVAL

申请号：

BRPI1010243

公开号：

BRPI1010243A2

申请日:

2010.03.02

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11&bgr；-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably R1 represents a hydrogen or OR1 represents an ester or an ether. R2 represents a naphthyl or a 1,2,3,4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. R3 represents a methyl or ethyl； R4 and R&prime；4 represent a hydrogen.

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