Refers to a compound of formula I, where X is CH2, c = o R IS h, thieno [2,3-c] pyridin - 5 - 5.5 - ilcarbonil, dioxidodibenzo [B, d] - 3 - il, dimetibenzoil 2.5 - [2 - (trifluoromethyl) phenyl] acetyl, among others.Preferred compounds are: 4 - (thieno [2,3-c] pyridin - 5 - ilcarbonil) - 1.4 - diazatricilo 4,3,1,13,8 [] UNDECANE 4 - (3 - clorobenzoil) - 1.4 - diazatricilo 4,3,1,13,8 [] UNDECANE n - [4 - (1,4 - diazatricilo [] 4,3,1,13,8 ethyl-2 - (ilcarbonil) phenyl] acetamide 4 - [5 - (2,6 - dimetoxifenil) pyridin-3-yl] - 1.4 - diazatricilo 4,3,1,13,8 [] Dean 4 - (6 - Chloro - 1,3-benzoxazol-2 - yl) - 1.4 - diazatriciclo 4,3,1,13,8 [] UNDECANE among others.These compounds are Selective modulators of neuronal alpha7 nnr include alfa4beta2, useful in the treatment of senile dementia, picks disease, Dementia associated with Down Syndrome, acute pain, nociceptive Pain, headaches, among othersREFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES CH2, C=O R ES H, TIENO[2,3-c]PIRIDIN-5-ILCARBONIL, 5,5-DIOXIDODIBENZO[b,d]TIEN-3-IL, 2,5-DIMETIBENZOIL, [2-(TRIFLUOROMETIL)FENIL]ACETIL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(TIENO[2,3-c]PIRIDIN-5-ILCARBONIL)-1,4-DIAZATRICILO[4,3,1,13,8]UNDECANO 4-(3-CLOROBENZOIL)-1,4-DIAZATRICILO[4,3,1,13,8]UNDECANO N-[4-(1,4-DIAZATRICILO[4,3,1,13,8]UNDECAN-4-ILCARBONIL)FENIL]ACETAMIDA 4-[5-(2,6-DIMETOXIFENIL)PIRIDIN-3-IL]-1,4-DIAZATRICILO[4,3,1,13,8]UNDECANO 4-(6-CLORO-1,3-BENZOXAZOL-2-IL)-1,4-DIAZATRICICLO[4,3,1,13,8]UNDECANO ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES SELECTIVOS DE NNR NEURONALES QUE COMPRENDEN ALFA7, ALFA4BETA2 UTILES EN EL TRATAMIENTO DE DEMENCIA SENIL, ENFERMEDAD DE PICK, DEMENCIA ASOCIADA AL SINDROME DE DOWN, DOLOR AGUDO, CEFALEAS, DOLOR NOCICEPTIVO, ENTRE OTROS
