A system and related methods for wireless medication compliance sensing is provided. The system includes a housing having a plurality of medication compartments. A breakable substrate is positioned on at least one side of the housing, wherein the breakable substrate covers an opening to the plurality of medication compartments. A sensor array is positioned on the at least one side of the housing. The sensor array has a plurality of resistors, wherein one of the plurality of resistors is positioned across one of the openings of the plurality of medication compartments. A wireless tag is connectable to the sensor array, the wireless tag comprising a transmitter, an accelerometer, and a sensing circuit, wherein the sensing circuit is adapted to scan the sensor array upon activation of the accelerometer, and wherein the transmitter transmits a signal having scanned sensor array data externally from the wireless tag.
