抗CD20抗體配製劑

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专利权人:

Novartis AG

发明人:

BRISBANE, Charlene, E.,KETKAR, Amol, Sharad,LASHMAR, Ulla, Tove

申请号：

HK10108319.5

公开号：

HK1141979B

申请日:

2010.09.02

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 100mM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/