The invention relates to an isolated multipotent glomerular mesenchymal stem cell derived form adult human kidney(hGL-MSC), which is characeterised by the marker profile CD133,CD146,CD34 and CD105. A method of preparing the hGL-MSC of the invention form decapsulated glomeruli is also disclosed, as well as the suse of the hGL-MSC of the invention in the regenerative treatment of the kidney, particularly for the treatment of injuries or diseases affecting renal glomeruli