1. The compound of formula (I) in which R is hydrogen, fluoro, methyl or ethyl, R is methyl, difluoromethyl or trifluoromethyl, R is hydrogen or fluoro, R is hydrogen, methyl or ethyl, and R is hydrogen or methyl, or a pharmaceutically acceptable salt, hydrate and / or solvate. 2. The compound of formula (I) according to claim 1, wherein R is hydrogen, or a pharmaceutically acceptable salt, hydrate and / or solvate thereof. 3. The compound of formula (I) according to claim 1, wherein R is hydrogen or fluorine, or a pharmaceutically acceptable salt, hydrate and / or solvate thereof. The compound of formula (I) according to claim 1, in which R is hydrogen or fluorine, R is methyl or difluoromethyl, R is hydrogen or fluorine, R is hydrogen or methyl, and R is hydrogen, or a pharmaceutically acceptable salt, hydrate and / or solvate thereof. The compound of formula (I) according to claim 1, wherein the compound is selected from the group consisting of race-2-methyl-4- (3-methyl-1H-indazol-5-yl) -6- (trifluoromethyl) -1,4-dihydropyridine- 3,5-dicarbonitrile； (4R) -2-methyl-4- (3-methyl-1H-indazol-5-yl) -6- (trifluoromethyl) -1,4-dihydropyridin-3,5-dicarbonitrile； (4S ) -2-methyl-4- (3-methyl-1H-indazol-5-yl) -6- (trifluoromethyl) -1,4-dihydropyridin-3,5-dicarbonitrile； rac-2- (difluoromethyl) -4- (6-fluoro-3-methyl-1H-indazol-5-yl) -6-methyl-1,4-dihydropyridin-3,5-dicarbonitrile； (4R) -2- (difluoromethyl) -4- (6-fluoro -3-methyl-1H-indazol-5-yl) -6-methyl-1,4-dihydropyridin-3,5-dicarbonitrile； (4S) -2- (difluoromethyl) -4- (6-fluoro-3-methyl -1H-ind zol-5-yl) -6-methyl-1,4-dihydropyridin-3,5-dicarbonitrile； 2,6-bis (difluoromethyl) -4- (3-methyl-1H-indazol-5-yl) -1, 4-dihydropyridin-3,5-dicarbonitrile； 2,6-bis (difluoromethyl) -4- (6-fluoro-3-methyl-1H-indazol-5-yl) -1,4-dihydropyridin-3,5-dicarbonitrile ； irats-4- (6-fluoro-1H-indazol-5-yl) -2-methyl-6- (trifluoromethyl) -1,4-dihydropyridin-3,5-dicarbonitrile； or a pharmaceutically acceptable salt thereof, hyd1. Соедине
