БУФАЛИ Симоне (IT),БАУДНЕР Бабара (IT),О'ХЕЙГАН Дерек (US),СИНГХ Манмохан (US),ОХЕЙГАН Дерек (US)
申请号：
RU2014140521
公开号：
RU2014140521A
申请日:
2013.03.08
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An immunogenic composition comprising diphtheria toxoid, tetanus toxoid, pertussis toxoid, aluminum salt adjuvant, and a TLR agonist, wherein the composition contains an excess (measured in Lf units) of tetanus toxoid compared to diphtheria toxoid. 2. The composition of claim 1, wherein the TLR agonist is a TLR4 agonist or a TLR7.3 agonist. The composition of claim 1, wherein the TLR agonist is adsorbed on an adjuvant that is an aluminum salt. A composition according to claim 1, in which 1, 2 or 3 of the toxoids are adsorbed / adsorbed on an adjuvant, which is an aluminum salt. A composition according to claim 1, wherein the Al concentration is ≤0.5 mg / ml. The composition of claim 1, wherein the aluminum salt is aluminum hydroxide. A composition according to claim 1, wherein the TLR agonist is a compound of the formula 'K' described in the present invention, or a pharmaceutically acceptable salt thereof. The composition of claim 1, wherein the TLR agonist is compound K2.9. The composition of claim 1, wherein the TLR agonist comprises at least one adsorbable moiety that allows it to be adsorbed on insoluble metal salts. The composition of claim 9, wherein the adsorbed moieties are a phosphate or phosphonate group. The composition of claim 1, wherein the TLR agonist is described by formula (C), (D), (E), (F), (G), (H), (I), (II), (J) or (K ) defined in the description, or is 3d-MPL.12. A composition according to claim 1, wherein the TLR agonist is one of compounds 1-102 as defined in document 13, or a pharmaceutically acceptable salt thereof. A composition according to claim 1, comprising a histidine buffer. An immunogenic composition comprising diphtheria toxoid, tetanus toxoid, pertussis toxoid and adjuvant, which is an oil-in-water emulsion, where1. Иммуногенная композиция, содержащая дифтерийный анатоксин, столбнячный анатоксин, коклюшный анатоксин, адъювант, представляющий собой соль алюминия, и агонист TLR, причем композиция содержит избыток (измеренный в е
