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2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME
专利权人:
发明人:
Trevor M. PENNING,Adegoke ADENIJI,Lawrence J. MARNETT
申请号:
US15769565
公开号:
US20180305305A1
申请日:
2016.10.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention includes 2-β-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are (R)-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.
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