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Substituted oxadiazole compounds
专利权人:
Soo Sung Ko;Jagabandhu Das
发明人:
Jagabandhu Das,Soo Sung Ko
申请号:
US13825595
公开号:
US09187437B2
申请日:
2011.09.23
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed are compounds of Formula (I):or stereoisomers, N-oxides, salts, or prodrugs thereof; wherein: Ring A is phenyl or 5- to 6-membered heteroaryl; (i) R1 and R2 are independently C1-C4 alkyl; or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; Q is phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents; and R3, L1, L2, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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