THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;EMORY UNIVERSITY
发明人:
Young-Sup Yoon,JiWoong Han,Sang Ho Lee,Changwon Park
申请号：
US14698899
公开号：
US20150307840A1
申请日:
2015.04.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of producing endothelial or endothelial like cells comprising exposing fibroblasts with ETV2 under conditions such that the fibroblasts are modified to form a pool of cells expressing increased levels of endothelium surface markers compared to the fibroblasts. In certain embodiments, the disclosure relates to using endothelial like cells reported herein for the treatment of vascular, cardiac, and wound healing indications.
