KIM SUNG WUK,JUN SUNG SOO,MIN CHANG HEE,KIM YOUNG WOONG,KANG MIN SEOK,OH BYUNG KYU,PARK SE HWAN,KIM YONG EUN,KIM DUCK,LEE JI SUN,OH JU HOON
申请号：
IN201728004293
公开号：
IN201728004293A
申请日:
2017.02.06
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
BIGUANIDE DERIVATIVE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
