The United States of America, as represented by the Secretary, Department of Health and Human;The Johns Hopkins University
发明人:
Joel Schneider,Gerald Brandacher,Daniel Smith,Gabriel Brat,Johanna Grahammer
申请号：
US15545647
公开号：
US20180000983A1
申请日:
2016.01.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. The peptides comprise photo-caged glutamate residues with a neutral photocage that can be photolytically selectively uncaged to disrupt the fibrillar network and trigger an irreversible gel-sol phase transition of the hydrogel. Isolated peptides for making the disclosed hydrogels are provided, as are methods of using the peptide hydrogels in anastomosis procedures.
