JAESCHKE, GEORG,LINDEMANN, LOTHAR,RICCI, ANTONIO,RUEHER, DANIEL,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PH12015500496
公开号：
PH12015500496B1
申请日:
2015.03.06
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein Y is N or CH or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula (I) are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinsons disease, and gastroesophageal reflux disease (GERD).
