WILD, KENNETH, D.,TREANOR, JAMES, J.,S.,HUANG, HAICHUN,INOUE, HEATHER,ZHANG, TIE, J.,MARTIN, FRANK
申请号：
HRP20060033
公开号：
HRP20060033B1
申请日:
2006.01.24
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.Ovaj izum osigurava antitijela koja reagiraju s ili se vežu na ljudski čimbenik rasta živaca (NGF) te neutraliziraju njegovu funkciju. Izum također osigurava farmaceutske pripravke spomenutih antitijela i metode za neutraliziranje funkcije NGF-a, a posebno za tretman poremećaja koji imaju veze s NGF-om (poput kroničnog bola) i to davanjem farmaceutski učinkovite količine anti-NGF antitijela. Metode za otkrivanje količine NGF-a u uzorku s pomoću antitijela također su predstavljene ovim izumom.
