Kruse, Cornelis G.,Keizer, Hiskias G.,Zorgdrager, Jan,Van Loevezijn, Arnold,Van Der Neut, Martina A.W.,Iwema Bakker, Wouter I.
申请号：
AU2007298987
公开号：
AU2007298987B8
申请日:
2007.09.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
This invention concerns sulfonylpyrazoline carboxamidine derivatives asantagonists of 5-HT receptors, to methods for the preparation ofthese compounds and to novel intermediates useful for their synthesis. The inventionalso relates to the uses of such compounds and compositions, particularly theiruse in administering them to patients to achieve a therapeutic effect in Parkinson'sdisease, Huntington's chorea, schizophrenia, anxiety, depression,manic depression, psychoses, epilepsy, obsessive compulsive disorders, mooddisorders, migraine, Alzheimer's disease, age related cognitive decline,mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia,binge eating disorders, panic attacks, akathisia, attention deficit hyperactivitydisorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol,nicotine or benzodiazepines, pain, disorders associated with spinal traumaor head injury, hydrocephalus, functional bowel disorder, Irritable BowelSyndrome, obesity and type-2 diabetes. The compounds have the general formula(1), wherein the symbols have the meanings given in the description.
