The present invention relates to compounds of Formula I or a pharmaceutically salt or solvate thereof, which impair PBX-dependent transcription regulation, particularly which affect the binding of HOX to PBX and their use in a number of applications, including the reduction of aberrant cell division, e.g. to treat certain cancers, and to maintain pluripotency of stem cells, e.g. to maintain the pluripotency of stem cells during culture expansion. wherein R1, R2 and R3 are as defined herein.
