Qing GE,Brian H. JOHNSTON,Mark A. BEHLKE,Heini ILVES,Anne DALLAS
申请号：
US15725870
公开号：
US20180148723A1
申请日:
2017.10.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Aspects of the present invention include the production and use of chemically modified RNAi agents (e.g., shRNAs) in gene silencing applications. The chemically modified RNAi agents disclosed herein have reduced immunostimulatory activity, increased serum stability, or both, as compared to a corresponding RNAi agent not having the chemical modification. Compositions containing chemically modified RNAi agents according to aspects of the present invention (including pharmaceutical compositions) and kits containing the same are also provided.
