SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION
发明人:
LEE, Dong Ki,이동기
申请号：
KRKR2011/006632
公开号：
WO2012/053741A3
申请日:
2011.09.07
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to nucleic acid molecules having a novel structure which induce RNAi, and to the uses thereof. More particularly, the present invention relates to nucleic acid molecules which have a novel structure and which increase the rate of inhibiting the expression of target genes by configuring the structure to have a first strand of 24-121 nt in length provided with a partial region complementary to a target nucleic acid, and a second strand of 13-21 nt in length provided with a region which forms a complementary bond with the partial region complementary to the target nucleic acid of the first strand. The invention further relates to a method for inhibiting the expression of the target genes using the nucleic acid molecules. The nucleic acid molecular structure according to the present invention can increase a gene inhibition rate, or increase the inhibition rate of the target genes by improving the bonding strength to the same target genes together with siRNA through the introduction of antisense DNA, antisense RNA, ribozyme, and DNAzyme, or by causing synergistic cleavage. Furthermore, the nucleic acid molecules according to the present invention enables the continuance time of a gene inhibition rate to be lengthened. Thus, the nucleic acid molecules inducing RNAi are useful since they replace the conventional siRNA molecules applicable to the treatment of cancer or of viral infection using siRNA.Cette invention concerne des molécules dacides nucléiques dotées dune nouvelle structure qui induisent des ARNi, et leurs utilisations. Plus particulièrement, cette invention concerne des molécules dacides nucléiques dotées dune nouvelle structure et qui augmentent le taux dinhibition de lexpression de gènes cibles grâce à une structure ayant un premier brin de 24 à 121 nt de long pourvu dune région partielle complémentaire dun acide nucléique cible, et un second brin de 13 à 21 nt de long pourvu dune région qui forme une liaison complémentaire avec
