ВЭН Чжиган (US),УИНСТОН Уилльям М. мл. (US),БАЙ Айлинь (US),МИТЗИ Кристан (US),ВЕЙЛЕР Солли (US),ЧЕН Тин (US),ДЬЮРИС Ене (US)
申请号：
RU2012153241/10
公开号：
RU2012153241A
申请日:
2011.05.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. An isolated antibody that binds FGFR2 human, comprising: (i) a variable domain of an immunoglobulin heavy chain comprising CDR, comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 5 and SEQ ID NO: 47, CDR, comprising the amino acid sequence of SEQ ID NO: 38 and CDR, comprising the amino acid sequence of SEQ ID NO: 11 and (ii) an immunoglobulin variable region light chain CDRs comprising the amino acid sequence of SEQ ID NO: 41, CDR, comprising the amino acid sequence of SEQ ID NO: 42 and CDR, comprising the amino acid sequence of SEQ ID NO: 14.2. An isolated antibody that binds FGFR2 human, comprising: (i) a variable domain of an immunoglobulin heavy chain comprising CDR, comprising the amino acid sequence of SEQ ID NO: 5, CDR, comprising the amino acid sequence of SEQ ID NO: 38 and CDR, comprising the amino acid sequence of SEQ ID NO: 11 and (ii) an immunoglobulin variable region light chain CDRs comprising the amino acid sequence of SEQ ID NO: 41, CDR, comprising the amino acid sequence of SEQ ID NO: 42 and CDR, comprising the amino acid sequence of SEQ ID NO: 14.3. An isolated antibody that binds FGFR2 human, comprising: (i) a variable domain of an immunoglobulin heavy chain comprising CDR, comprising the amino acid sequence of SEQ ID NO: 47, CDR, comprising the amino acid sequence of SEQ ID NO: 38 and CDR, comprising the amino acid sequence of SEQ ID NO: 11 and (ii) a variable region comprising CDRs of an immunoglobulin light chain amino acid sequence of SEQ ID NO: 41, CDR, comprising the amino acid sequence of SEQ ID NO: 42 and CDR, the amino acid comprising SEQ1. Выделенное антитело, которое связывает FGFR2 человека, содержащее:(i) вариабельную область тяжелой цепи иммуноглобулина, содержащую CDRH1, содержащий аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:5 и SEQ ID NO:47, CDRH2, содержащий аминокислотную последовательность SEQ ID NO:38, и CDRH3, содержащий аминокислотную последовательность SEQ
