A pet boot having therapeutic properties is worn on a pets injured or sensitive paw to facilitate healing and or provide protection. The therapeutic pet boot includes an external boot member having a shaft and a paw portion constructed to form a cavity integrated therein appointed to receive an injured paw of a pet. The therapeutic pet boot further includes an internal therapeutic member appointed to be received within the cavity of the external boot member and is appointed to intimately contact the injured paw. The therapeutic pet boot is appointed to be worn on the injured paw of the pet to facilitate healing. The internal therapeutic member may comprise a gel bootee having a massaging gel sole or may comprise a gel inner layer or gel insole. Advantageously, the internal therapeutic member may directly deliver medicament to the paw and/or provide cold treatment or hot treatment therapies to the paw, while providing cushioning, shock absorption and protection from dirt and debris.