NEMUNAITIS, JOHN, J.,SENZER, NEIL,MAPLES, PHILLIP, B.,RAO, DONALD
申请号：
EP10840035
公开号：
EP2515916A4
申请日:
2010.12.20
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-&bgr； through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
