The present invention relates to the method for the construct for preparing base what liposome, the construct includes the target peptide modified by hydrophobic parts reconstructed in liposome, especially target antigen peptide, and is related to closing the antigenic construct that uses the method to obtain. The invention further relates to the construct caused with what treatment albumen matter conformational disease (proteopathy) or relevant disease and illness (such as alzheimer's disease) in therapeutic and diagnostic purposes.本發明涉及製備基於脂質體的構建體的方法，所述構建體包含在脂質體中重構的通過疏水性部分修飾的目標肽，尤其是目標抗原性肽，並涉及關於使用所述方法獲得的抗原性構建體。本發明進一步涉及所述構建體在用於治療蛋白質構象病(proteopathy)引起或相關的疾病及病症（諸如阿爾茲海默氏病）中的治療性及診斷性用途。
