Brenda F. Baker,Anne B. Eldrup,Muthiah Manoharan,Balkrishen Bhat,Richard H. Griffey,Eric E. Swayze,Thazha P. Prakash
申请号：
US14834873
公开号：
US09771578B2
申请日:
2015.08.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.
