MOLÉCULE ASSOCIÉE À L'APPARITION DE LA GOUTTE, ET PROCÉDÉ ET TROUSSE POUR ÉVALUER LA DIATHÈSE DE MALADIES ASSOCIÉES À L'ACIDE URIQUE ET DE MALADIES ASSOCIÉES À UNE INFLAMMATION, ET OBJET D'EXAMEN ET MÉDICAMENT
Shinomiya, Nariyoshi;The University of Tokyo;Matsuo, Hirotaka
发明人:
申请号：
EP15737793.8
公开号：
EP3095865A4
申请日:
2015.01.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
To specify a molecule associated with the onset of gout so as to provide a method for evaluating a diathesis of uric acid-related diseases and a diathesis of inflammation-related diseases, an evaluation kit for carrying out the method, an inspection object, and a drug, on the basis of the molecule specified above, for contributing to the early treatment and prevention of the uric acid-related diseases and inflammation-related diseases. The molecule includes any one protein and cDNA of CNIH2-PACS1, ALDH2, MYL2-CUX2, GCKR, MAP3K11, NPT4, ABCG2, HIST1H2BF/HIST1H4E, HIST1H2BE/HIST1H4D and FAM35A, or proteins of combination thereof with GLUT9, NPT1, URAT1, or NXRN2, and is capable of selectively inducing gout. A molecule includes protein and cDNA of an ABCG2 variant and is capable of selectively and ATP-dependently decreasing urate excretion.
