A patient vital sign monitoring system comprises a frame, a bar code list and a vital sign monitor. The vital sign monitor uses a bar code reader to reads measurement bar codes or function-setting bar codes of the bar code list and generates an action instruction corresponding to a measurement instruction of one measurement bar code or a function-setting instruction of one function-setting bar code to a control unit of a host computer module. According to the action instruction, the control unit triggers an optional vital sign measurement unit to undertake the selected vital sign measurement and transmit the result to a database, or sets a function of the vital sign monitor. The patient vital sign monitoring system is easily transported to and flexibly applied to different wards, avoiding inaccuracy of manual transcription and errors in the transfer process, and saving the time the nursing personnel spend in transcription.