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UTILISATION D'UN DÉRIVÉ DE BENZOPHÉNONE OU D UN SEL DE CELUI-CI ET INHIBITEUR DE TNF EN COMBINAISON ET COMPOSITION PHARMACEUTIQUE CONTENANT LE DÉRIVÉ OU LE SEL DE CELUI-CI ET L'INHIBITEUR
专利权人:
LTD.;TOYAMA CHEMICAL CO.
发明人:
AIKAWA, YUKIHIKO,SHIOZAWA, SHUNICHI
申请号:
EP09724165
公开号:
EP2258361A4
申请日:
2009.03.25
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Disclosed are use of a benzophenone derivative represented by general formula (I) or a salt thereof and one or more TNF± inhibitors in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereof and one or more TNF± inhibitors. The use and the composition are useful for treatment or prevention of autoimmune diseases and the like. (In the formula, R 1 represents an optionally substituted heterocyclic group, a substituted phenyl group or the like; Z represents an alkylene group or the like; R 2 represents a carboxyl group, which may be protected by an alkyl group, or the like; R 3 represents an optionally protected hydroxyl group or the like; R 4 represents an optionally substituted cycloalkyloxy group or the like; and R 5 represents a hydrogen atom or the like.)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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