Andrew James McCarroll;Marc Geoffery Hummersone;David Cousin;Jihong Zhang;Sharon Jennings;John Gareth Williams;Malcolm Francis Graham Stevens
发明人:
Malcolm Francis Graham Stevens,David Cousin,Sharon Jennings,Andrew James McCarroll,John Gareth Williams,Marc Geoffery Hummersone,Jihong Zhang
申请号：
US12808604
公开号：
US08450479B2
申请日:
2008.12.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.
