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CYTOTOXIC HEXIM1 PEPTIDES AND USES THEREOF
专利权人:
AGENCY FOR SCIENCE; TECHNOLOGY AND RESEARCH
发明人:
CHAO, Sheng-Hao
申请号:
SG11201705759S
公开号:
SG11201705759SA
申请日:
2016.03.03
申请国别(地区):
SG
年份:
2017
代理人:
摘要:
Disclosed are isolated cytotoxic peptides having similar sequences as the basic region (BR) of Hexamethylene Bisacetamide Inducible Protein 1 (HEXIM1). Preferred embodiments include QLGKKKHRRRPSKKKRHW (SEQ ID No: 3). QLGRRRHRRRPSRRRRHW (SEQ ID No: 4) and QLGKKILAARPSKKKRHW (SEQ ID No: 5). Also encompassed are isolated nucleic acid molecules encoding for the claimed peptides, vectors comprising the isolated nucleic acids, compositions comprising peptides conjugated to cell-targeting or penetrating peptides or antibodies, nucleic acid molecules or vectors expressing conjugates thereof; methods of treating or preventing diseases or conditions, including cancers and obesity as well as a method of eliminating undifferentiated stem cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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