The present invention includes methods for the inhibition of post-operativeadhesion formation between tissuesur-faces in a body cavity having been subjected to a surgical procedure,which methods involve administering a histamine H4receptor antagonist, systemically, directly to tissue surfaces in the bodycavity, or both, and to delivery vehicles and compositionssuit-able for use for local, non-systemic administration of a drug to the bodyand directly to tissue within a body cavity having beensubjected to a surgical procedure